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It has been shown that GLP-1 receptor agonists can enhance insulin sensitivity in effector organs, promote fatty acid oxidation, reduce lipogenesis and improve glucose metabolism after binding to the receptor (247)

Furthermore, pyocyanin has been found to disrupt CFTR Cl - transport by inhibiting the endocytic recycling of CFTR and inactivating the airway epithelial vacuolar ATPase, which reduces the expression and trafficking of CFTR, hence disrupting Cl - transport (175, 176)

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